“Poor ctDNA clearance has been shown to predict disease recurrence and overall survival. This study will look at ctDNA clearance specific to patients treated with FOLFIRINOX chemotherapy protocol in rectal cancer. Title: Prospective feasibility study for correlation of ct DNA with radiological/ metabolic assessment in locally advanced high risk rectal cancer treated with neoadjuvant induction chemotherapy with triplet mFOLFIRINOX protocol sequenced with long course chemoradiation therapy followed by surgery. CTDNA will be used to assess response, with the aim to establish the best sequencing for patients in this study population.” Idea 2: Presented by Doctor Ankit Jain “This study will randomise patients into patients who receive long course chemoradiotherapy, followed by surgery and patients who will receive chemotherapy upfront in induction, followed by long course chemoradiotherapy and then surgery. Title: Optimal Sequencing of Chemotherapy in Total Neoadjuvant Therapy for Rectal Cancer (OSCAR) Idea 1: Presented by Associate Professor Zee Wan Wong Take a look below at a snapshot of some of ideas presented on the day. Finally, participants had to indicate their interest in assisting to refine and improve the proposed studies. They then voted on the level of enthusiasm for each idea, ranking from ‘highly interested’ to ‘no interest’. Participants were invited to consider the many aspects of the ideas presented, including potential impact, requirements to ensure its success, potential to become AGITG studies and more. It serves as a platform for embryonic ideas to be developed, to foster collaboration between both researchers and industry, and to future-proof patient treatment options. Launched in 2019, the Idea Generation Workshop enables us to deliver on our strategic goals to accelerate the pace of discovery and connect researchers. Ideas focused on neoadjuvant treatment in rectal cancer. This workshop was held in collaboration with TROG Cancer Research. The fifth Idea Generation Workshop was held virtually on, facilitated by Associate Professor Sam Ngan (Radiation Oncologist) and Dr Deborah Wright (Lower GI Surgeon). Early Career Research Award for Excellence in AGITG Research.AGITG Member Fundraiser of the Year Award.Christine Aiken Memorial Award for Excellence in AGITG Study Coordination.Merck-AGITG Clinical Research Fellowship in GI Cancer.Gastro-Intestinal Stromal Tumour (GIST).
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